What is the Cross-Linked Hyaluronic Acid Dermal Filler ?

The Cross Linked Hyaluronic Acid Dermal Filler is a sterile injectable, pyrogen-free gel, which is composed of a cross-linked hyaluronic acid from a non-animal origin in a phosphate buffer saline solution. The gel is latex free, viscoelastic, clear, colorless and biodegradable.
Synthetically cross-linking the HA improves stability, longevity, and elastoviscous properties. The cross linker we use is 1,4-butanedioldiglycidyl ether (BDDE), which forms irreversible carbon bridges between the hyaluronic acid molecules, causing an increase of the in vivo duration of the product.
Crosslinking transforms the linear chains of hyaluronic acid into a three dimensional structure that is more resistant to enzymatic degradation, while maintaining its biocompatibility. Thus, a water insoluble gel is formed and remains stable in the tissue. It is slowly resorbed over a period of months through an isovolumetric degradation. A higher degree of cross-linking produces more resistance to degradation (although there is a limit of how much cross-linking can be used), as does a larger particle size.
Another factor that influences the consistency of the final product sis the concentration of HA in the gel. Measured in mg/mL, the concentration of HA comprises both soluble molecules (free particles of HA) and insoluble particles (cross-linked). Gels with a higher rigidity have a better ability to withstand the dynamic forces that occur during movements of facial muscles; thus being more suitable for filling deeper and sharper grooves, such as nasolabial and nasogenian folds.
The crosslink density directly affects this ability to absorb water. With a greater amount of crosslinks, the chains of HA will be closer and less flexible, making the connection with water more difficult.

Radiant Dermal Fillers

Radiant Vision

Radiant Even

Radiant Finesse

Radiant Allure

Radiant Soft

Radiant Derm

Radiant Ultra

Radiant Soft

Radiant Derm

Radiant Ultra

ILLUSTRATION NAME COMPOSITION CONCENTRATION VOLUME NEEDLES INDICATION DEPTH DURATION*
Radiant
Vision
Sodium hyaluronate, BDDE, phosphate buffersolution 8mg/ml 1ml TSK Correction of under-eye circles. Into the superficial dermis. 4-5 months
Radiant
Even
Sodium hyaluronate, BDDE, phosphate buffersolution 10mg/ml 1ml TSK Non-surgical rhinoplasty and the correction of the décolleté area. Into the superficial dermis. 4-5 months
Radiant
Finesse
Sodium hyaluronate, BDDE, phosphate buffersolution 12mg/ml 1ml TSK Correction of medium depth wrinkles in the skin of the hands. Into the superficial dermis. 6-7 months
Radiant
Allure
Sodium hyaluronate, BDDE, phosphate buffersolution 14mg/ml 1ml TSK Correction of medium wrinkles in the skin around the lips and perioral area. Into the superficial and mid dermis. 6-7 months
Radiant
Soft
Sodium hyaluronate, BDDE, phosphate buffersolution 18mg/ml 1ml TSK Superficial lines, fine to moderate wrinkles and minor skin damage. The product can be used on wrinkles, lines and creases around the mouth. Into the superficial and mid dermis. 12 months
Radiant
Derm
Sodium hyaluronate, BDDE, phosphate buffersolution 23mg/ml 1ml TSK Correction of deep and severe facial wrinkles and folds. Into the deep dermis. Over 12 months
Radiant
Ultra
Sodium hyaluronate, BDDE, phosphate buffersolution 26mg/ml 1ml TSK For volume augmentation and facial shape restoration. For lips contour and volume.

The product can be used on severe wrinkles.

Into the deep dermis or subcutaneously for volume augmentation and the mid to deep dermis for injection into lips. Over 12 months

*Based on extensive data gathered from surgeons who have performed hundreds of thousands dermal filler injections.

SALES GROWTH

Based on marketing data gathered for the years 2015 and 2016, where approx. 353.000 and 648.000 cross-linked HA dermal fillers were sold respectively. Meanwhile, no adverse events were reported.

SAFETY PERFORMANCE

The post marketing clinical follow-up conducted for the year 2016 shows that out of the 113.237 patients treated, 90.3% reported a very significant improvement score, 12% reported a much improved score, 0.78%, reported an improved score and 0.0% reported no change.
The post marketing clinical follow-up conducted for the year 2015 shows that out of the 10.932 patients treated, 46.4% reported a very significant improvement score, 21.5% reported a much improved score and 17% reported an improved score. No unexpected adverse events were reported.

Based on existing post marketing clinical follow-up data gathered from surgeons who have performed hundreds of thousands dermal filler injections, during 2016.

Based on existing post marketing clinical follow-up data gathered from surgeons who have performed hundreds of thousands dermal filler injections, during 2015.

Are you interesting in distributing the best dermal filler products in the market? You have come to the right page. Radiant Filler is an official distribution arm of the Dr. Korman Laboratory. We have a strong business and partner network of distributors, market specialists, practitioners, and dermatologists who recommend our products to the end-users. Just check the dermal filler before and after page to check the real pictures of our happy end-users! The market of quality dermal filler is hot and approximately 648000 cross-linked dermal fillers were sold alone in 2016 (double the numbers of 2015). To add on, approximate 90% end-users reported that they saw a very significant improvement in the removal of wrinkles, creases, and lines from the skin after applying our solution which is a remarkable figure.

These impressive figures state that there is a huge market potential for aesthetic medicine products (dermal fillers, anti-wrinkle products, and bio-revitalization products) made from genuine hyaluronic acid.

If you are interested to become a distributor of dermal filler products, please get in touch with us today. For more information, please download our dermal filler catalog right now which contains in-depth information on our manufacturing process, product catalog, and contact information of our lab and representative. We will discuss all the business prospects over the call and understand each other. If we connect well, we will further share our distribution strategy and help you in the best possible manner to market the products effectively and clock good sales numbers/profit margins in the first year itself.

Join the aesthetic medicine product industry today as a distributor and bring smile on millions of faces!