Dr. Korman Laboratories Ltd.’s Dermal Fillers Manufacturing Technology
- Dermal Fillers and Volumizing Fillers
- DDCI-OT technology
Dr. Korman Laboratories focuses the on production of dermal fillers and volumizing fillers (monophasic and biphasic in accordance with Customer’s requirements).
Dr. Korman Laboratories fillers and volumizing fillers are produced in line with Dynamic Double Cross linked Optimization Technology (DDCI-OT technology).
- Stabilized Hyaluronic Acid
- 1, 4-butanediol diglycidyl ether
Based on stabilized hyaluronic acid, the gel has total biological compatibility, it is viscoelastic, sterile, apyrogenic, predictable, clear and colorless; its biodegradation does not affect tissue architectonics.
Dr. Korman Laboratories Ltd. uses the most commonly employed cross-linker,the 1, 4-butanediol diglycidyl ether (BDDE), which forms irreversible carbon bridges between the hyaluronic acid molecules, causing an increase of the in vivo duration of the product.
- Monophasic poly-densified hyaluronic acid
Crosslinking transforms the linear chains of hyaluronic acid into a three-dimensional structure that is more resistant to enzymatic degradation, while maintaining its biocompatibility.
The crosslink density directly affects this ability to absorb water. With a greater amount of crosslinks, the chains of hyaluronic acid will be closer and less flexible, making the connection with water more difficult.
The manner in which crosslinking is performed during the manufacturing process leads to the dermal fillers’ characterization as biphasic combined with monophasic poly-densified hyaluronic acid based fillers.
- Monophasic poly-densified fillers
- Hyaluronic acid
In biphasic products, the crosslinked hyaluronic acid is sieved through a screen to isolate crosslinked HA particles of uniform size. On the other hand, monophasic fillers are not sieved and contain a mixture of randomly sized and shaped pieces. Monophasic poly-densified fillers add additional hyaluronic acid and further cross-linking after the initial mix.
Dr. Korman Laboratories Ltd.’s dermal fillers properties create a gel with different zones of densities, permitting optimal spreading throughout the tissue whereas conventional hyaluronic acid fillers would not be able to fill the smallest gaps.
- Elastic component G
The elastic component, represented as G’, is another important physical property. It reflects the ability of a gel to resist deformation when a force is applied against it. A gel with a greater elastic component will be firmer and stronger and will undergo fewer changes in shape when pressure is applied to it.
Dr. Korman Laboratories Ltd.’s dermal fillers in the concentrations of 14 mg/ml, 12 mg/ml,10 mg/ml and 12 mg/ml have lower elastic modulus therefore they will be more appropriate for areas that do not suffer as much pressure, such as the lachrimal fold and lips.
Dr. Korman Laboratories Ltd.’s dermal fillers in the concentrations of 18 mg/ml, 23 mg/ml and 26 mg/ml will have a greater ability to generate volume and support. Additionally, it has an increased ability to withstand the daily dynamic forces such as movements of facial muscles; therefore, it is more suitable for areas such as the nasolabial and nasogenian grooves. A more fluid gel in an area that suffers high pressure would not resist deformation and would be pushed towards the area of lowest resistance, resulting in worse clinical results and lower procedure durability.